Cholinergic Modulation of Narcoleptic Attacks in Double Orexin Receptor Knockout Mice
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چکیده
منابع مشابه
Cholinergic Modulation of Narcoleptic Attacks in Double Orexin Receptor Knockout Mice
To investigate how cholinergic systems regulate aspects of the sleep disorder narcolepsy, we video-monitored mice lacking both orexin (hypocretin) receptors (double knockout; DKO mice) while pharmacologically altering cholinergic transmission. Spontaneous behavioral arrests in DKO mice were highly similar to those reported in orexin-deficient mice and were never observed in wild-type (WT) mice....
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0018697